Recent management of T2D, obesity and the MetS has been transformed by such (second‐generation) glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) as liraglutide and semaglutide, and, more recently, dual agonists of GLP‐1 and glucose‐dependent insulinotropic polypeptide (GIP) receptors, such as tirzepatide. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.