It showed that in osteoporosis patients, CP (P < 0.01), LIPT1 (P < 0.05), SLC25A3 (P < 0.001), and UBE2D3 (P < 0.01) were upregulated, while the expression levels of CDKN2A (P < 0.05), DBH (P < 0.01), DLST (P < 0.05), LOXL2 (P < 0.05), SLC31A1 (P < 0.05), and UBE2D1 (P < 0.01) were downregulated. The gene discussed is UBE2D1; the disease is osteoporosis.