Deficiency or inhibition of PLD2 protects the expression of tight junction proteins such as claudin-5, occludin, and ZO-1 by regulating the phosphatidic acid/signal transducer and activator of transcription three phosphorylation pathway, thereby mitigating sepsis-associated acute lung injury (Qian et al., 2023). This evidence concerns the gene TJP1 and Sepsis.