Abbreviations: ANA, antinuclear antibody; ARS, aminoacyl-tRNA synthetase; CCP, cyclic citrullinated peptide; dsDNA, double-stranded DNA; GBM, glomerular basement membrane; MDA5, melanoma differentiation-associated gene 5; MPO-ANCA, myeloperoxidase-antineutrophil cytoplasmic antibody; PR3-ANCA, proteinase 3-antineutrophil cytoplasmic antibody; RNP, ribonucleoprotein; Scl-70, topoisomerase I; SRP, signal recognition particle; SS, Sjögren’s syndrome; TIF-γ, transcription intermediary factor 1-gamma. Here, IFIH1 is linked to Sjogren syndrome.