To demonstrate the utility of our pipeline in uncovering biologically meaningful spatial patterns, we analyzed the distribution of cells expressing high levels of phosphorylated NDRG1 (pNDRG1), a novel DNA repair protein implicated in chemoresistance and replication fork stability, in PDAC AsPC xenografts treated with gemcitabine, a standard-of-care chemotherapy used in the treatment of pancreatic cancer. This evidence concerns the gene XRCC6P5 and familial pancreatic carcinoma.