A study by Chaisaingmongkol et al. identified 22 potential driver genes, including APC, KMT2C, GNAS, KRPB1, ADAMTS20, ERBB3, ERBB2, ATM, KAT6B, MAP2K4, and RNF43, and found that eight genes (TP53, ARID1A, ARID2, CSMD3, RYR2, NF1, PRKDC, and PSIP1) are shared between iCCA and hepatocellular carcinoma (HCC), indicating potential overlap in their molecular pathways [32]. Here, PRKDC is linked to hepatocellular carcinoma.