CXCR6 and hepatocellular carcinoma: In addition, the report summarized that increased LCA inhibits the expression of C-X-C motif chemokine ligand 16 (CXCL16), a separate ligand of CXCR6, which suppresses hepatic CSCR6+ natural killer T (NKT) cell aggregation and interferon γ (IFN-γ) production, and promotes HCC development [53].