Moreover, subsets of the vascular cohort with aneurysmal rupture, early rupture, or multiple affected family members exhibited even more 5′-located mutations (median amino acid positions: 1811, P = 0.0018; 1671, P = 0.0052; and 1587, P = 0.0003, respectively), further supporting a potential positional effect of PKD1 mutations on vascular risk in ADPKD.47 This evidence concerns the gene PKD1 and autosomal dominant polycystic kidney disease.