To determine whether treatment responses correlated with specific subtypes of FGN renal pathology, we determined the complete or partial response rates among patients with mesangial sclerosis, proliferative FGN defined by the presence of crescents or endocapillary hypercellularity or intense (≥ +3) immunofluorescent staining for IgG or C3. This evidence concerns the gene C3 and Diffuse mesangial sclerosis.