With regard to immunosuppressive therapy, our data correspond to those of Askling et al., who found that 14% of patients with rheumatoid arthritis (RA) treated with tumor necrosis factor inhibitors and/or methotrexate who were initially seroprotected, had seroreverted 2 years after a 2-dose hepA vaccination series [16]. Here, TNF is linked to rheumatoid arthritis.