Aside from CD8+ T cell‐specific distinctions which influence the level of immunogenicity in any given donor, as discussed above, other factors such as the timing of protein production and abundance of protein during infection,39 peptide processing,40 peptide affinity for HLA‐I molecules41 or even the combination of other HLA‐I molecules within an individual42, 43 all have the potential to influence peptide presentation and subsequently CD8+ T‐cell activation.33 The gene discussed is CD8A; the disease is infection.