MGMT and glioblastoma: Tumor shape has previously been suggested as a potential prognostic factor in glioblastoma patients.12–14 In a recent study, we assessed tumor shape in patients with glioblastoma and found that contact surface area (CSA) and sphericity index (SI) were independent prognostic factors for survival and linked to MGMT (O6-methylguanine-DNA methyltransferase) methylation status and EOR.15 We hypothesized that tumor shape could be of clinical importance in patients with LGG as well, with extent of resection (EOR) as a possible mediator.