Studies indicate that female CKD patients, particularly those with uncontrolled diabetes, exhibit a higher prevalence of anemia compared to males, emphasizing the need for gender-specific management strategies.16 Poor glycemic control in diabetic patient’s further increases anemia risk, exacerbated by chronic inflammation and reduced erythropoietin production.17 Additionally, iron deficiency affects approximately 50% of CKD patients and is associated with increased risks of kidney failure and mortality, significantly impairing quality of life in advanced disease stages.18,19. This evidence concerns the gene EPO and anemia (phenotype).