We found that the VExUS ≥1 group had a significantly higher proportion of male patients and elevated levels of NT-proBNP, cTnI, CVP, cumulative fluid balance, as well as a higher rate of diuretic use compared to the VExUS 0 group, suggesting a direct association between the severity of venous congestion and right ventricular dysfunction. The gene discussed is NPPB; the disease is hyperemia.