Numerous algorithms have been developed, either aetiology-specific[15], [16], [17] or multi-aetiology,5 incorporating clinical parameters (e.g. age, sex, BMI, or diabetes) and biological parameters (e.g. gamma-glutamyl transferase [GGT], aspartate aminotransferase [AST]/alanine aminotransferase [ALT], platelets, or albumin),16,18,19 serum proteins,[20], [21], [22] or single nucleotide polymorphisms.23 The gene discussed is GPT; the disease is diabetes mellitus.