Inhibition of IL-13 yielded no reduction in airway eosinophils in 64 patients with uncontrolled asthma (Austin et al., 2020), however inhibition of alarmin IL-33 reduced blood eosinophil counts in 296 patients with moderate-to-severe asthma (Wechsler et al., 2021). This evidence concerns the gene IL13 and asthma.