Other proteins seem less promising as biomarkers; though OX40/OX40L interaction contributes to the allergic T cell response and helps sustain memory T cells, inhibition of the OX40/OX40L had no effect on airway hyperresponsiveness or blood eosinophil counts (Gauvreau et al., 2014a). This evidence concerns the gene TNFSF4 and airway hyperresponsiveness.