IL4 and asthma: High IgE levels may also be associated to T2 high asthma (Busse et al., 2015; Shrestha et al., 2018), and like FeNO the T2 high-associated increased total IgE levels decreased during inhibition of alarmin IL-33 (Wechsler et al., 2021), IL-13 (Scheerens et al., 2014) and dual IL-4 and IL-13 signalling (Wenzel et al., 2013).