Inactivation of Sirt2 affected the transcriptional response of mouse β-cells to hyperglycemia and downregulated the hyperglycemia-activated signatures UPR (“Unfolded Protein Response” - misfolding stress proteins Herpud1, Hspa5, and Wfs1) and genes of ribosomal proteins (Rplp0, Rpl6, Rpl8, and Rps27a) (96). The gene discussed is WFS1; the disease is Hyperglycemia.