Apart from that, novel markers of T1DM complications were found: genes encoding VCAN, TIMP1, TNC, C3, CP, EIF4B, RICTOR, PRKCB for diabetic kidney disease; Fxyd7 and Atp1b1 for mechanical allodynia; Cirbp, Mt1, Rbm3, Hmgb2, Mt2 for diabetic retinopathy. This evidence concerns the gene HMGB2 and type 1 diabetes mellitus.