Lipoprotein-associated phospholipaseA2 (Lp-PLA2) and Netrin-1 were also shown to be involved in the activation mechanisms of SBIs in DKD individuals, suggesting that the RBP4/Lp-PLA2/Netrin-1 signaling pathway may participate in the regulation of cognitive dysfunction in DKD patients with SBIs (99). The gene discussed is NTN1; the disease is diabetic kidney disease.