While several BCL-2 family proteins, such as BCL-2 and BCL-xL, are implicated in AML pathogenesis, Mcl-1 has emerged as a particularly compelling target due to its rapid turnover, unique structural dynamics, and its central role in conferring resistance to chemotherapeutics and apoptosis (Ramsey et al. 2018; Wang et al. 2021). Here, BCL2 is linked to acute myeloid leukemia.