This study detected the ALDH2 gene polymorphism in 352 angina pectoris patients treated at the Second Hospital of Jiaxing, 359 angina pectoris patients treated at the First Affiliated Hospital of Henan University of Science and Technology, and 373 angina pectoris patients treated at the Second Affiliated Hospital of Guilin Medical University from September 2021 to August 2023. Here, ALDH2 is linked to angina pectoris.