FOXO3 and malignant colon neoplasm: Hydroxytyrosol promoted ROS production, which activated the PI3K/AKT/FOXO3 pathway with subsequent regulation of FOXO3 targets, including catalase and SOD, resulting in the induction of apoptosis in DLD1 colon cancer cells and a reduction in cellular antioxidant defenses (Sun et al. 2014).