Furthermore, all major pathological contributors are integral to Alzheimer's disease pathogenesis as inflammation (Amelimojarad et al., 2024), oxidative stress (Bhandari et al., 2024), dyslipidemia (de Oliveira et al., 2024), and insulin resistance (Kale et al., 2024). The gene discussed is INS; the disease is early-onset autosomal dominant Alzheimer disease.