Other notable receptor and ion channel DEGs addressed by CBD treatment in 3xTg-AD animals included regulatory proteins Necab2 [for adenosine A2A and metabotropic glutamate type 5 receptors (Xie et al., 2022)] and Gprasp2 [for M1 muscarinic acetylcholine and calcitonin receptors (Edfawy et al., 2019)]; the H+-gated, Na+ permeant ion channel Asic4 (Lin et al., 2015); and the voltage-gated K+ channels Kcng2 (Guo et al., 2023) and Kcnq4 (Lee et al., 2021). This evidence concerns the gene GPRASP2 and Alzheimer disease.