In wild-type controls (Figure 1B, Supplementary Table 2), 21 AD-associated DEGs (Table 1) were regulated in the same direction (Egfl7, Efna1, Unc5c, Fn1, Ddit1, Efemp1, Fabp3, Pdk4, Ltc4s, C1qb, Il33, Bcam, Cgnl1, C1qc, Aebp1, Ptgis, Saa3, Fcrls, C1qa, C4b, and Ednrb) as in 3xTg-AD animals and thus are not distinct for neuropathology onset in 3xTg-AD animals. Here, IL33 is linked to Alzheimer disease.