Of all the genes common to longitudinal and cross-sectional analyses in 3xTg-AD vs. wild-type animals above, note that Kndc1, Sfrp1, Rbp4, and Etv4 also appear as upregulated DEGs in CBD-treated wild-type vs. vehicle animals at 6.5 mo of age (Supplementary Table 23). This evidence concerns the gene ETV4 and Alzheimer disease.