In addition, note that the most extreme DEGs in 3xTg-AD animals (log2 fold change > 15) as H2-Q2 and Sult4a1 were no longer DEGs in comparison with the CBD-treated 3xTg-AD group, whereas Tdrd5, Cyp2f2, and Rag2 remained (Figure 1C, Supplementary Table 6). This evidence concerns the gene RAG2 and Alzheimer disease.