Finally, other longitudinal blood DEGs such as Mafa [insulin gene expression in pancreatic β cells (Kataoka et al., 2002)] and Mlxipl [regulates glycolysis and lipogenesis (Abdul-Wahed et al., 2017); involved in both AD and coronary artery disease (Loika et al., 2023)] were eliminated in response to CBD in 3xTg-AD animals. This evidence concerns the gene MAFA and Alzheimer disease.