For comparisons of CBD-treated 3xTg-AD vs. CBD-treated wild-type, additional upregulated pathways included OAS antiviral response, class I MHC-mediated antigen processing and presentation, multiple sclerosis signaling, and immunoregulatory interactions between a lymphoid and a non-lymphoid cell (Figure 8A) with gene overlap patterns similar to CBD-treated 3xTg-AD vs. vehicle (Figures 7B, 8B). Here, SMOC1 is linked to multiple sclerosis.