For regulation of neuronal growth, Bmp4 is a ligand of bone morphogenetic receptors (can activate Acvr1), whereby its increased expression correlates to decreased hippocampal cell proliferation during AD (Li et al., 2008) and white matter destruction following chronic hypoperfusion of the brain (Uemura et al., 2018). The gene discussed is BMP4; the disease is Alzheimer disease.