Of the most extreme DEGs as identified in 3xTg-AD animals (|log2 fold change| > 15; downregulated H2-Q2 and Tdrd5 and upregulated Sult4a1, Cyp2f2, and Rag2), H2-Q2, Tdrd5, and Cyp2f2 were upregulated DEGs in CBD-treated wild-type animals. Here, TDRD5 is linked to Alzheimer disease.