IGF1 and Alzheimer disease: Pathways that were commonly upregulated in both CBD-treated groups to a similar extent [–log(p-value) ≈ 2] but with a relatively enhanced z-score in 3xTg-AD animals include regulation of IGF transport and uptake by IGFBPs and post-translational protein phosphorylation, primarily based on the expression of the Tmem132a gene (Supplementary Table 20).