Five upregulated pathways of the CBD-treated 3xTg-AD vs. 3xTg-AD vehicle group included (from greatest to least) interferon alpha/beta signaling, role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza, interferon gamma signaling, pathogen induced cytokine storm signaling, and neuroinflammation signaling (Figure 7A). Here, IFNG is linked to Alzheimer disease.