For cross-group comparisons (e.g., cross-sectional brain analyses at wk 8), the order of presentation is 3xTg-AD vehicle vs. wild-type vehicle, 3xTg-AD CBD-treated vs. 3xTg-AD vehicle, wild-type CBD-treated vs. wild-type vehicle, and 3xTg-AD CBD-treated vs. wild-type CBD-treated. Here, OPN1MW is linked to Alzheimer disease.