With continuing consideration of DEGs not necessarily selective for AD pathology originally identified in longitudinal analyses of 3xTg-AD mice (Figure 1A, Supplementary Table 1), C920006O11Rik, Timm8b, Necab2, Gprasp2, Kcng2, Asic4, Kcnq4, Lockd, Angptl6, Sidt1, and Acat3 also appeared as DEGs in the cross-sectional analysis of vehicle 3xTg-AD vs. wild-type mice (Supplementary Table 21). This evidence concerns the gene ANGPTL6 and Alzheimer disease.