Other notable lncRNAs that coincided with AD onset in 3xTg-AD animals and were addressed by CBD treatment include C920006O11Rik (Jia et al., 2020) and Lockd involved in the transcriptional regulation of the cyclin-dependent kinase inhibitor 1B (Cdkn1b) gene (Sung et al., 2018). Here, CDKN1B is linked to Alzheimer disease.