For CBD-treated 3xTg-AD vs. CBD-treated wild-type mice cross-sectional analyses in blood, downregulated DEGs include F12, Ncr1, and Apoe and upregulated DEGs include Ndufa7, Cox7a2, miR144, Ankrd36, Prok2, Timm8b, Lockd, Iqsec3, and Spink10 (Supplementary Table 24). The gene discussed is APOE; the disease is Alzheimer disease.