However, note that other DEGs in blood appeared as homologs to the observed AD DEGs in the brains of 3xTg-AD mice as Rnase1, Ms4a4b, Ccr5/9, Aqp11, Usp46, Cxcl14, Ms4a7, and Kcnn3. The gene discussed is USP46; the disease is Alzheimer disease.