In wild-type controls (Figure 1B, Supplementary Table 2), 21 AD-associated DEGs (Table 1) were regulated in the same direction (Egfl7, Efna1, Unc5c, Fn1, Ddit1, Efemp1, Fabp3, Pdk4, Ltc4s, C1qb, Il33, Bcam, Cgnl1, C1qc, Aebp1, Ptgis, Saa3, Fcrls, C1qa, C4b, and Ednrb) as in 3xTg-AD animals and thus are not distinct for neuropathology onset in 3xTg-AD animals. The gene discussed is EFNA1; the disease is Alzheimer disease.