APOE and Alzheimer disease: In addition, CBD potentially presents a novel experimental (e.g., cyclodextrins) and therapeutic (e.g., statins) alternative to managing membrane cholesterol homeostasis (Guard et al., 2022) as relevant to the AD risk factor apolipoprotein E ε4 allele (APOE4; Sun et al., 2023b) while central to cardiovascular and cognitive health (Rashid et al., 2023).