Relatively few DEGs were apparent for CBD-treated vs. vehicle wild-type mice as 7 downregulated [e.g., Cxcr5 and Midline 1 (Mid1)] and 10 upregulated [e.g., Nurim (Nrm), Lymphocyte transmembrane adaptor 1 (Lax1), SLAM family member 6 (Slamf6), Immunoglobulin kappa constant (Igkc) and Immunoglobulin kappa chain variable 12-41 (Igkv12-41)] genes while not overlapping with those of CBD-treated 3xTg-AD animals (Figure 6C, Supplementary Table 29). This evidence concerns the gene IGKC and Alzheimer disease.