PROK2 and Alzheimer disease: For CBD-treated 3xTg-AD vs. CBD-treated wild-type mice cross-sectional analyses in blood, downregulated DEGs include F12, Ncr1, and Apoe and upregulated DEGs include Ndufa7, Cox7a2, miR144, Ankrd36, Prok2, Timm8b, Lockd, Iqsec3, and Spink10 (Supplementary Table 24).