Exact matches for AD-selective genes as determined in the longitudinal 3xTg-AD analyses for onset of AD (Figure 1A, Supplementary Table 1) include Ramp3, Tamalin, Sema4c, the lncRNA Map2k3os, Rin1, F12, Acvr1, Iqck, Tagln3, Scg5, Wfs1, Cacna2d4, Ncr1, Esr1, Ndufa7, Cox7a2, Acacb, Gls2, Bmp4, Mgat3, Ppp1r3c, Vgf, Gpr6, Hapln2, Oprd1, Ntsr1, Lrfn5, Nap1l2, Kndc1, Pcsk2, Cckbr, Tmem63c, Prkar1b, the miRNA Mir144, Mei1, Tacr3, Lin7a, Gria4, Npsr1, Scara3, Ankrd36, Sfrp1, Insm1, Snap91, St8sia3, Pcdh9, Rgs7, Rbp4, Chrna2, Etv4, Pld6, Adamts13, Kcnk2, Slc17a7, Prok2, and Ncan. This evidence concerns the gene PROK2 and Alzheimer disease.