Exact matches for AD-selective genes as determined in the longitudinal 3xTg-AD analyses for onset of AD (Figure 1A, Supplementary Table 1) include Ramp3, Tamalin, Sema4c, the lncRNA Map2k3os, Rin1, F12, Acvr1, Iqck, Tagln3, Scg5, Wfs1, Cacna2d4, Ncr1, Esr1, Ndufa7, Cox7a2, Acacb, Gls2, Bmp4, Mgat3, Ppp1r3c, Vgf, Gpr6, Hapln2, Oprd1, Ntsr1, Lrfn5, Nap1l2, Kndc1, Pcsk2, Cckbr, Tmem63c, Prkar1b, the miRNA Mir144, Mei1, Tacr3, Lin7a, Gria4, Npsr1, Scara3, Ankrd36, Sfrp1, Insm1, Snap91, St8sia3, Pcdh9, Rgs7, Rbp4, Chrna2, Etv4, Pld6, Adamts13, Kcnk2, Slc17a7, Prok2, and Ncan. The gene discussed is ACACB; the disease is Alzheimer disease.