As upregulated in 3xTg-AD animals, Exoc3l2 is an endothelial factor involved in angiogenesis [upregulated by vascular endothelial growth factor (Vegfa)] and with gene mutations associated in AD pathology of human subjects (Wu et al., 2017; Seshadri et al., 2010). The gene discussed is VEGFA; the disease is Alzheimer disease.