With relevance to notable genes marked in the brain for AD pathology and CBD treatment in 3xTg-AD animals, Eif3j2, Eno1b, Apol11b, and Cxcl13 commonly mark both biological sample compartments with DNA nucleotidylexotransferase (Dntt) regulated in opposing directions in brain relative to blood (Supplementary Table 32). The gene discussed is CXCL13; the disease is Alzheimer disease.