Pathways that are significantly reversed in wild-type relative to 3xTg-AD mice (Supplementary Table 15) and vice versa (Supplementary Table 16) include endocannabinoid neuronal synapse pathway; breast cancer regulation by Stathmin 1; neurotransmitter release cycle; K+ channels; molecular mechanisms of cancer; CREB signaling in neurons, S100 family signaling; neurovascular coupling signaling; synaptogenesis signaling; and extracellular matrix organization. Here, S100B is linked to Alzheimer disease.