Downregulated pathways that emerged with CBD treatment in wild-type but not 3xTg-AD include phagosome formation; CREB signaling in neurons; S100 family signaling; G-protein coupled receptor signaling; breast cancer regulation by stathmin 1; molecular mechanisms of cancer; and class B/2 (secretin family receptors; Supplementary Table 19). The gene discussed is CREB1; the disease is Alzheimer disease.