CREB1 and Alzheimer disease: With a commonly upregulated pathway as complement cascade signaling, downregulated pathways in CBD-treated wild-type animals that were upregulated in untreated 3xTg-AD animals include extracellular matrix organization; CREB signaling in neurons; synaptogenesis signaling; neurexins and neuroligins; neurovascular coupling; and breast cancer regulation by Stathmin 1 (Figures 2A, 5A).