GPR6 and Alzheimer disease: For select endocannabinoid-related genes, the CBD receptor gene Gpr6 (Laun et al., 2019) was no longer indicated as a DEG but Dagla enzyme gene [for 2-arachidonoglycerol (2-AG) production; Schuele et al., 2022] remained upregulated regardless following CBD treatment in 3xTg-AD mice.