CACNA2D4 and Alzheimer disease: In CBD-treated 3xTg-AD vs. vehicle mice, all of these genes marked for AD pathology were either reversed in expression (downregulated to upregulated: Ramp3, Sema4c, Rin1, Acvr1, Iqck, Tagln3, Scg5, and Cacna2d4; upregulated to downregulated: Mgat3, Tmem63c, Prkar1b, Kcnk2, and Ncan) or no longer appeared as a DEG in 3xTg-AD mice (Supplementary Table 22).