Of those DEGs indicated in conditions independent of or in addition to AD pathology, Timm8b, Susd4, Tmsb4x, Kcnt2, Lockd lncRNA, Jam3, Kcnk3, Des, Klhdc7a, Abca8a, Gpd1, Plin1, and Thrsp were commonly regulated in the same direction for both 3xTg-AD and CBD-treated 3xTg-AD mice. This evidence concerns the gene JAM3 and Alzheimer disease.