Of all the AD DEGs (Table 1), 103 (43%) were included in this list, with Srgap1, Lrfn5, Myt1l, Kndc1, Pcsk2, Cacna2d3, Prkar1b, Pcdh9, Mei1, Foxp2, Lin7a, Pth2r, St8sia3, Slc17a7, Rbp4, and Etv4 as significantly reversed in the opposite direction of expression in wild-type mice relative to 3xTg-AD. Here, CACNA2D3 is linked to Alzheimer disease.