DES and Alzheimer disease: Of those DEGs indicated in conditions independent of or in addition to AD pathology, Timm8b, Susd4, Tmsb4x, Kcnt2, Lockd lncRNA, Jam3, Kcnk3, Des, Klhdc7a, Abca8a, Gpd1, Plin1, and Thrsp were commonly regulated in the same direction for both 3xTg-AD and CBD-treated 3xTg-AD mice.