Relative to 3xTg-AD vehicle, all ≈100 metabolites that differentiated 3xTg-AD vs. wild-type vehicle mice were absent in CBD-treated 3xTg-AD animals with exception of phosphate, which was increased in 3xTg-AD relative wild-type vehicle but decreased in CBD-treated 3xTg-AD animals relative to 3xTg-AD vehicle. The gene discussed is OPN1MW; the disease is Alzheimer disease.