With relevance to notable genes marked in the brain for AD pathology and CBD treatment in 3xTg-AD animals, Eif3j2, Eno1b, Apol11b, and Cxcl13 commonly mark both biological sample compartments with DNA nucleotidylexotransferase (Dntt) regulated in opposing directions in brain relative to blood (Supplementary Table 32). This evidence concerns the gene DNTT and Alzheimer disease.