PCSK2 and Alzheimer disease: Other AD genes that were obviated as DEGs in response to CBD at AD onset included those that were downregulated (e.g., Ramp3, Tamalin, Sema4c, the lncRNA Map2k3os, Rin1, F12, Acvr1, Iqck, Tagln3, Scg5, Wfs1, Cacna2d4, Ncr1, and Esr1) and upregulated (e.g., Ndufa7, Cox7a2, Acacb, Gls2, Bmp4, Mgat3, Ppp1r3c, Vgf, Gpr6, Hapln2, Oprd1, Ntsr1, Lrfn5, Nap1l2, Pcsk2, Cckbr, Tmem63c, Prkar1b, the miRNA Mir144, Mei1, Tacr3, Lin7a, Gria4, Npsr1, Scara3, Ankrd36, Insm1, Snap91, St8sia3, Pcdh9, Rgs7, Chrna2, Pld6, Adamts13, Kcnk2, Slc17a7, Prok2, and Ncan).