SFRP1 and Alzheimer disease: In comparison with CBD-treated 3xTg-AD animals (Figure 1C, Supplementary Table 6), nine AD DEGs as C1qa, C1qb, Cyp1b1, Sfrp1, Myh4, C1s1, Ppp1r3c, Pck1, and Atp1a2 were regulated in the same direction in CBD-treated wild-type animals.