The most significantly enriched pathways included the TNF signaling pathway, Lipid and atherosclerosis, Kaposi sarcoma-associated herpesvirus infection, AGE-RAGE signaling pathway in diabetic complications, Rheumatoid arthritis, Chagas disease, Transcriptional misregulation in cancer, Coronavirus disease-COVID-19, IL-17 signaling pathway, and Pertussis. The gene discussed is TNF; the disease is rheumatoid arthritis.