The results of this study demonstrated that RP-CME is associated with both ocular and systemic immune dysregulation based on the following: 1) the RP patients with CME exhibited ocular upregulations of IL-23, I-309, and GROα; 2) the peripheral %LYMPH was significantly higher in patients with CME compared to those without CME; and 3) the MFA revealed potential associations between the CME status of RP patients and several IL-23-related inflammatory network parameters (i.e., aqueous IL-23, IL-8, GROα, eotaxin, I-309, and serum IL-23 and IFN-γ) and the peripheral immune markers %LYMPH and LNR. Here, CXCL1 is linked to retinitis pigmentosa 1.