CSF2 and neoplasm: In addition, under the influence of GM‐CSF and IFN‐γ, immature neutrophils in the TME differentiate into hybrid neutrophils with antigen‐presenting cell (APC) characteristics, which also have APC characteristics and can capture tumor‐associated antigens and migrate to the tumor‐draining lymph nodes (LNs), where they form synapses with the T cells and present the antigens to the T cells, which in turn triggers an antitumor immune response [149].