Besides, NETs also can trigger the sequential upregulation of a series of genes encoding inflammatory mediators, such as COX2, IL‐1α/β, CSF‐1, and so on, which in turn can trigger tumor inflammatory response and promote tumor metastasis through the activation of the pathway represented by the TLR4/9–COX2 axis [201]. This evidence concerns the gene TLR4 and neoplasm.