CXCL1 and neoplasm: In addition, ELR‐positively expressing subpopulations of TANs can promote tumor angiogenesis by directly binding to the receptor CXCR2 expressed on tumor vessels or indirectly recruiting leukocyte subpopulations, and ELR+ chemokines such as CXCL1–3 can also promote angiogenesis, and CXCR2 itself is an important factor in promoting the release of neutrophils, so the ELR+ neutrophil subpopulations are important in promoting tumor angiogenesis [160, 161].