As for the relationship between PINK1 levels and disease severity, cerebral PINK1 mRNA expression levels were tightly correlated with clinical scores and hematoma size following acute intracerebral hemorrhage (22), and PINK1 levels in cerebrospinal fluid and serum were highly relevant to the memory, executive function, and language domains of patients with Alzheimer’s disease (23). This evidence concerns the gene PINK1 and early-onset autosomal dominant Alzheimer disease.