The volcano plot highlighted a 10% increase in LDL TGs (LDTG, L1TG, L6TG) in highly active RA, and reduced small, dense HDL subclasses (H4CH, H4A1, H4A2, H4PL), Apolipoprotein A1 (TPA1, HDA1) and A2 (TPA2, HDA2), Cholesterol (HDCH) as well as LDL-Chol (LDCH), particularly of intermediate density LDL particles (L2CH, L2PL, L3CH, L3FC, L3PL, L4CH, L4PL, L4FC) in remission. The gene discussed is APOA1; the disease is rheumatoid arthritis.