PMP22 and multiple sclerosis: Neuraxial anesthesia has been described in case reports with uneventful outcomes [11], but potential risks, such as unpredictable block spread, local anesthetic neurotoxicity in demyelinated fibers, and theoretical neurological worsening, are largely extrapolated from data in multiple sclerosis and other demyelinating neuropathies, given the scarcity of CIDP-specific evidence.