Clinical examination at that time raised suspicion of unilateral thyroid-associated orbitopathy (TAO), related to GD.As part of the initial workup two years prior, investigations were conducted, including serum thyroid-stimulating hormone (TSH), anti-TSH receptor antibodies (anti-TSH-R), thyroid peroxidase antibodies (anti-TPO), thyroid ultrasound, and a head CT scan. The gene discussed is TPO; the disease is thromboangiitis obliterans.