RCT: randomized controlled trial; IVF: in vitro fertilization; ART: assisted reproductive technology; ICSI: intracytoplasmic sperm injection; PCOS: polycystic ovary syndrome; GnRH: gonadotropin-releasing hormone; CPR: clinical pregnancy rate; LBR: live birth rate; LH: luteinizing hormone; hsCRP: high-sensitivity C-reactive protein. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.