TB is the single most frequent opportunistic infection in HIV-infected personsand is usually due to reactivation of latent infection, although primary infection risk is also greatly heightened [3].Clinical manifestation of TB among HIV-infected individuals is immune status-dependent; those with a good CD4 count present withclassical pulmonary TB, whereas in advanced immunosuppression, atypical or extrapulmonary disease is more common [4].Depressed CD4 count is related to characteristics such as disseminated TB, lack of cavitations and diagnostic complexity. This evidence concerns the gene CD4 and Opportunistic infection.