In a study of 60 Head and necksquamous cell carcinomas(HNSCC) cases (30 OSCC, 30 LSCC), NGS revealed TP53 mutations in 70% of oral squamous cell carcinoma (OSCC) and83% of laryngeal squamous cell carcinoma (LSCC). This evidence concerns the gene TP53 and laryngeal squamous cell carcinoma.