Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia with disturbances of carbohydrates, fatand protein metabolism resulting from defects in insulin secretion, insulin action, or both [1].According to WHO, Diabetes Mellitus (DM) stands out as one of the most formidable public health challenges in the 21st century.Presently, it impacts over 422 million individuals throughout the world and by 2030; this number is expected to have doubled. This evidence concerns the gene INS and Other metabolic disease.