The tumor microenvironment benefits from IL-6 through its ability to boost angiogenesis processes which involves vascularendothelial growth factor (VEGF) upregulation and enhances both endothelial cell proliferation and migration [3].Neovascularization happens to be essential for tumor growth and metastasis because it achieves nutrient and oxygen delivery toproliferating malignant cells. The gene discussed is VEGFA; the disease is neoplasm.