While the more extended regimen enables patients to stop treatment if an adverse reaction occurs, hospitalization and mortality due to primaquine-induced hemolysis have been reported in patients with G6PD deficiency in Brazil.10, 11, 12 Tafenoquine requires a semi-quantitative G6PD test before the prescription of tafenoquine (300 mg to adults) to those testing G6PD normal. Here, G6PD is linked to hemolysis.