Interestingly, these distinctivefeatures have attracted the interest of the scientific community beyondADCs, and many Cathepsin B-recognized peptide sequences have beenincluded in a wide number of PDCs, SMDCs, prodrugs, and cancer-imagingagents., The Val-Cititrulline (VCit) dipeptide isthe most established Cathepsin B-linker, recurring in 6 out of 9 FDA-approvedcleavable ADCs. The gene discussed is CTSB; the disease is cancer.