In this regard, it has been shown that circZKSCAN1 suppresses hepatocellular carcinoma stem cells by regulating the activity of RBP-sensitive X mental retardation protein (FMRP), whose downstream target gene is CCAR1, and showed that CCAR1 acts as a co-activator of the Wnt/β-catenin signaling pathway and is critical for generating an optimal TGF-β signaling response [6]. The gene discussed is CCAR1; the disease is hepatocellular carcinoma.