The sepsis markers were raised (CRP 301 mg/dL, PCT 6.9 ng/mL, and lactate 2.9 mmol/L), continued resuscitation his LRINEC score (laboratory risk indicator for necrotizing fasciitis) was 10 (CRP: 4 points, leukocytosis = 2, hyponatremia = 2 and raised serum creatinine = 2) suspected Fournier’s gangrene and planned immediate debridement, meanwhile computer tomography pelvis showed features of Fournier’s gangrene with small air foci seen perinium with edema (Figure 1). The gene discussed is CRP; the disease is Hyponatremia.