Xu et al. reported that methylation-regulated miR-124-1 attenuated tumorigenesis by inhibiting CASC3 expression, leading to the inactivation of the c-Jun N-terminal kinase (JNK), ERK, and p38-mitogen-activated protein kinase pathways in hepatocellular carcinoma (HCC).38 The gene discussed is MAPK8; the disease is hepatocellular carcinoma.