SMURF2 and non-small cell lung carcinoma: Notably, the natural compound schisandrin B has been reported to upregulate Smurf2 protein levels in colorectal cancer,43 while curcumin induces NLRP3-dependent pyroptosis in non-small cell lung cancer (NSCLC) (ncells by inhibiting Smurf2 ubiquitin ligase activity.44