Moreover, GSK2606414 inhibited nitrofurazone (NFZ)-induced elevation of ROS and Ca2+ levels, blocked the activation of the PERK-ATF4-CHOP signaling pathway, and consequently suppressed NFZ-induced apoptosis in NSCLC cells (98), which suggests that GSK2606414 may influence tumor cell fate through regulation of oxidative stress and calcium homeostasis. This evidence concerns the gene EIF2AK3 and non-small cell lung carcinoma.