CLDN7 and lung carcinoma: reported that the UBQLN1 deficiency in lung cancer cells promotes cytoskeleton formation, increases the expression of stromal phenotype-related proteins such as Vimentin, Snail, and ZEB1, and inhibits the expression of epithelial phenotypic markers such as E-Cadherin and Claudin1, ultimately regulating the EMT in lung cancer cells (47).