Moreover, GSK2606414 inhibited nitrofurazone (NFZ)-induced elevation of ROS and Ca2+ levels, blocked the activation of the PERK-ATF4-CHOP signaling pathway, and consequently suppressed NFZ-induced apoptosis in NSCLC cells (98), which suggests that GSK2606414 may influence tumor cell fate through regulation of oxidative stress and calcium homeostasis. The gene discussed is DDIT3; the disease is non-small cell lung carcinoma.