To further investigate the types of cells expressing CTHRC1, CST6, and AKR1B1 in tumor tissues, we utilized the GEO database datasets EMTAB8107 and GSE167297 to conduct a detailed analysis of CTHRC1, CST6, and AKR1B1 expression in STAD. This evidence concerns the gene CTHRC1 and gastric adenocarcinoma.