To further investigate the types of cells expressing CTHRC1, CST6, and AKR1B1 in tumor tissues, we utilized the GEO database datasets EMTAB8107 and GSE167297 to conduct a detailed analysis of CTHRC1, CST6, and AKR1B1 expression in STAD. The gene discussed is AKR1B1; the disease is gastric adenocarcinoma.