AKR1B1 and gastric cancer: AKR1B1, COL10A1, COL1A1, and other related genes (totaling 12 genes) had significantly high expression and were negatively associated with OS of patients with GC (HR>1.1, p < 0.05); CYP4X1, KCNQ1, and VSNL1 had significantly low expression and were positively associated with OS of patients with GC (HR < 0.9, p < 0.05) (Figure 4A).