RYR1 and cancer: Recent cutting-edge evidence positions copper metabolism as a critical nexus in cancer bioenergetics (68–70), notably influencing mitochondrial respiration and regulated cell death pathways through modulation of enzymes like cytochrome c oxidase (CcO)—the terminal complex of the mitochondrial electron transport chain, responsible for facilitating the transfer of electrons to oxygen and contributing directly to the generation of proton motive force for ATP synthesis (71).