RASSF1 and neoplasm: Keyword and co-citation analyses revealed four research phases: (1) early studies focused on promoter hypermethylation of tumor suppressor genes like RASSF1A; (2) an in-depth investigation of molecular mechanisms, including epithelial-mesenchymal transition and chromatin remodeling; (3) translational research involving HDAC inhibitors and DNA methylation biomarkers; and (4) recent advancements in multi-omics integration, synthetic lethality, and the study of epigenetics in the tumor microenvironment.