The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis identified 226 pathways, predominantly involving the advanced glycation end-product receptor for advanced glycation end-product signaling pathway in diabetic complications and lipid and atherosclerosis, suggesting that Osthole may intervene in prostate cancer through these pathways (P < 0.05) (Figures 1G, H). This evidence concerns the gene AGER and prostate carcinoma.