Specifically, our data demonstrate that: (1) sepsis triggers selective methylation alterations in hypothalamic gene promoters (particularly near transcription start sites); (2) these epigenetic modifications directly influence the expression of neuroendocrine regulators (e.g., POMC, AgRP); (3) the consequent hypothalamic signaling drives peripheral metabolic adaptations, including the observed skeletal muscle catabolism. Here, AGRP is linked to Sepsis.