CXCR6 and acute myeloid leukemia: ,38 These T cells, existing in a dysfunctional state, are characterized by high expression of GZMK and intermediate expression of PDCD1 and LAG3 and are referred to as “transitional T cells,” “pre-exhausted T cells,” or “TPEX cells.” Although tissue-resident memory T (TRM) cells generally express typical markers (e.g., CRTAM, RGS1, DUSP6, CD69, CXCR6, and TNFRSF9), TRM cells in aAVC-WT1-treated patients with AML expressed TRM signatures and typical exhaustion markers.