CD4 and neoplasm: When we assessed the timing between the reduction in leukemic blasts and CD4+ T or CD8+ T cell response to the peptide libraries, we found that the best tumor cell reduction occurred at the same time or a little after the peak of CD8+ T cell response (best tumor reduction was at days 28, 28, 42, and 28), whereas library-responsive T cell peak was at days 14, 28, 35, and 14 in A004, A005, A007, and A008, respectively.