In a mouse model of recurrent miscarriage constructed by Shahgaldi et al., MSC transplantation also upregulated the mRNA expression levels of placental VEGF, PlGF, and Flt1, while reducing the protein level of sFlt1, thus correcting the dysregulation of placental angiogenic factors, and improving pregnancy outcomes (Shahgaldi et al., 2022). The gene discussed is PGF; the disease is spontaneous abortion.