CD274 and colorectal cancer: In an in vivo colorectal cancer mice model, the ATR inhibitor M6620 (VX-970), when combined with cisplatin, carboplatin, or irinotecan and the anti–PD-L1 antibody avelumab, demonstrated significant anti-tumor activity; similarly, in the MB49 urothelial tumor model, the combination of carboplatin and avelumab also exhibited therapeutic efficacy (Alimzhanov et al., 2020).