TARDBP and amyotrophic lateral sclerosis: Activity of compounds in the THIQ protein assembly modulator chemical series appear to normalize an array of hallmarks of ALS pathology including elimination of stress-induced TDP-43 aggregates in stress granules, rescue of TDP-43 mis-localization (Figure 1), reversal of paralysis in worms (Figure 2), reversal of neurodegenerative markers in all models (Figures 2–4), normalization of weight in mice (Figure 4), and increased lifespan in worms and flies (Figures 2 and 3).