EZH2 and acute kidney injury: Collectively, we speculated that TRIM27 reduces GLIS1 DNA methylation and increases its expression, subsequently activating the Wnt/β‐catenin pathway by inhibiting PRC2 activity by mediating the ubiquitination degradation of EZH2, thereby promoting the dedifferentiation, proliferation, and migration of RTECs, and ultimately alleviating the development of RIRI‐induced AKI.