TRIM27 and acute kidney injury: Taken together, our results showed that TRIM27 reduced GLIS1 DNA methylation and increased its expression, subsequently activating the Wnt/β‐catenin pathway by inhibiting PRC2 activity through mediating EZH2 ubiquitination degradation, thereby promoting mRTECs dedifferentiation, proliferation, and migration and ultimately alleviating RIRI‐induced AKI (graphical abstract).